Chemography of Lysosome-like Structures in Olfactory Epithelium

At the light microscope level of resolution several chemicals have been shown to cause "fogging" of photographic film. Among these the principal reducing agents are glutathione, cysteine (1), hydrogen sulfide gas, and hydroquinone in animal tissue (17) . The -SH groups of the first three chemicals were shown to be responsible for the effect . Chemographic reactions of any kind at the electron microscope level of resolution are yet to be reported by other investigators . This note describes a unique application of electron microscope radioautographic techniques which demonstrated a chemical difference among three morphologically similar types of lysosome-